Erythrocyte glucose-6-phosphate dehydrogenase deficiency: evidence of differences between Negroes and Caucasians with respect to this genetically determined trait.
نویسندگان
چکیده
Erythrocyte glucose-6-phosphate dehydrogenase (G-6-P.D.) deficiency is associated with an increased susceptibility to hemolysis following ingestion of such agents as primaquine, naphthaline, sulfonamides, other drugs and the fava bean (1, 2). The incidence of this trait varies considerably among different population groups. Thus, it is relatively common among Negroes (3-7) and among Caucasians of Italian (4, 5), Greek (4, 5, 8) and Sephardic Jewish (9) extraction. On the other hand, the incidence of erythrocyte G-6-P.D. deficiency is low among subjects of Chinese (10) and Javanese (7) descent and is particularly rare among Ashkenazy Jews (9) and certain other Western Europeans (1-5). Data accumulated in both Negro (4, 5) and Caucasian populations (4, 5, 9) have suggested that this erythrocyte enzyme deficiency is due to a sex-linked gene of intermediate dominance. It has been assumed that the deficiency in G-6P.D. in these various population groups is a result of the same gene mutation. The explanation of the varied incidence of this enzyme defect in different racial groups has remained an intriguing problem. The present investigation has been concerned with further characterization of the relationship between the gene alteration and the resulting deficiency in red blood cell G-6-P.D. Among subjects with low erythrocyte G-6-P.D. activity, Caucasian males were found to have a more marked deficiency of this enzyme than Negro males. Recently, it was reported (11) that Ne-
منابع مشابه
Serum lipoproteins in schoolboys in relation to glucose-6-phosphate dehydrogenase deficiency and thalassaemia trait.
There is now evidence that an increase in the low-density serum lipoproteins plays a part in the causation of degenerative vascular disease (Gofman, Jones, Lindgren, Lyon, Elliott, and Strisower, 1950; Kannel, Dawber, Kagan, Revotskie, and Stokes, 1961). Studies of serum cholesterol in different ethnic groups has shown important differences (Adlersberg and Schaefer, 1959), but it cannot yet be ...
متن کاملGlucose-6-phosphate Dehydrogenase Deficiency and Thalassaemia Trait
There is now evidence that an increase in the low-density serum lipoproteins plays a part in the causation of degenerative vascular disease (Gofman, Jones, Lindgren, Lyon, Elliott, and Strisower, 1950; Kannel, Dawber, Kagan, Revotskie, and Stokes, 1961). Studies of serum cholesterol in different ethnic groups has shown important differences (Adlersberg and Schaefer, 1959), but it cannot yet be ...
متن کاملDiagnosis of erythrocyte glucose-6-phosphate dehydrogenase deficiency in the negro male despite hemolytic crisis.
E RYTHROCYTE GLUCOSE-6-PHOSPHATE DEHYDROGENASE ( G-6PD ) DEFICIENCY is a frequent clinically-significant genetically-determined abnormality of man. On the basis of gene frequency of the enzyme deficiency, about 3,000,000 Negroes in the United States carry genes for this disorder.1 When exposed to certain drugs and chemical agents, clinically normal persons with G-6-PD deficiency experience hemo...
متن کاملGlucose-6-Phosphate Dehydrogenase Deficiency Associated with Thalassemia and Sickle Cell Anemia in an Iranian Family
Sickle cell-thalassemia associated with glucose- 6-phosphate dehydrogenese deficiency is reported in an Iranian family. The father had sickle trait and G.6.P.D. deficiency, the mother minor thalassemia, one of the sons siclc:le ceH-thailasemiia., the oth-er sickle cell trait; the daughter had sickle cell-thalassemia and was carrier of G.6.P.D. deficiellcy.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of clinical investigation
دوره 38 شماره
صفحات -
تاریخ انتشار 1959